Risk of MI for patient on abacavir calculator Gender: Female Male Current age in years: Cigarette smoker?: No Yes Diabetic?: No Yes ECG-left ventricular hypertrophy (LVH)?: No Yes Systolic blood pressure: unit: mm/Hg cm/Hg kPa Total cholesterol unit: mg/dL mmol/L HDL unit: mg/dL mmol/L  NNH Additional information: *Number needed to harm (NNH) is a measure for negative treatment effect and indicates the number of patients who need to be treated to observe the adverse effect of a treatment in one additional patient. It has been introduced first by Laupacis A, Sackett DL and Roberts RS in 1988. Laupacis A, Sackett DL, Roberts RS. An assessment of clinically useful measures of the consequences of treatment. N Engl J Med 1988; 318: 1728–1733. Abstract link The algorithms used for calculating the Framingham risk of MI are the exact same as published by: Anderson KM, Odell PM, Wilson PW, Kannel WB.: Cardiovascular disease risk profiles. Am Heart J. 1991 Jan;121(1 Pt 2):293-8. Abstract link Further information on abacavir related risk of MI can be found at: Sabin CA, Worm SW, Weber R, Reiss P, El-Sadr W, Dabis F, et al. Use of nucleoside reverse transcriptase inhibitors and risk of myocardial infarction in HIV-infected patients enrolled in the D:A:D study: a multi-cohort collaboration. Lancet 2008 Apr 26;371(9622):1417-26 Abstract link Further details on the use of number needed to harm in HIV-1 infected patients treated with abacavir can be found at: Kowalska JD, Kirk O, Mocroft A, Høj L, Friis-Møller N, Reiss P, Weller I, Lundgren JD. Implementing the number needed to harm in clinical practice: Risk of myocardial infarction in HIV-1 infected patients treated with abacavir. HIV Med 2010;11(3):200-208. Abstract link Updated: 23 Sep 2010